Math 146 As Men Age, Their Testosterone Levels Gradually Decrease

As men age, their testosterone levels gradually decrease. This may cause a reduction in lean body mass, an increase in fat, and other undesirable changes. Do testosterone supplements reverse some of these effects? A study in the Netherlands assigned 237 men aged 60 to 80 with low or low-normal testosterone levels to either a testosterone supplement or a placebo. The report in the Journal of the American Medical Association described the study as a “double-blind, randomized, placebo-controlled trial. ” Explain each of these terms to someone who knows no statistics. 1. Explain the meaning of the term “double-blind” study. A. Double-blind means that the researchers are not familiar with results concerning the investigated issue. B. Double-blind means that the treatment (testosterone or placebo) assigned to a subject was unknown to both the subject and those responsible for assessing C. the effectiveness of that treatment. D. Double-blind means that the subjects and those responsible for assessing the effectiveness of the treatment, were not known to each other. E. Double-blind means that the treatment (testosterone or placebo) assigned to a subject was unknown to the subject. 2. Explain the meaning of the term “randomized” experiment. True or False: “‘Randomized’ means that patients were randomly assigned to recieve either the testosterone suppliment or a placebo. “A. TrueB. False3. Explain the meaning of the term “placebo-controlled” trial. A. Placebo-controlled means that the study is an experiment rather than an observational study. B. Placebo-controlled means that the study did not use a placebo group in its design. C. Placebo-controlled means that the placebo group showed the same results as the treatment group. D. Placebo-controlled means that some of the subjects were given placebo.

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MATH 146 As men age, their testosterone levels gradually decrease

Question
As men age, their testosterone levels gradually decrease. This may cause a reduction in lean body mass, an increase in fat, and other undesirable changes. Do testosterone supplements reverse some of these effects? A study in the Netherlands assigned 237 men aged 60 to 80 with low or low-normal testosterone levels to either a testosterone supplement or a placebo. The report in the Journal of the American Medical Association described the study as a “double-blind, randomized, placebo-controlled trial.” Explain each of these terms to someone who knows no statistics.

1.Explain the meaning of the term “double-blind” study.

A.Double-blind means that the researchers are not familiar with results concerning the investigated issue.
B.Double-blind means that the treatment (testosterone or placebo) assigned to a subject was unknown to both the subject and those responsible for assessing C.the effectiveness of that treatment.
D.Double-blind means that the subjects and those responsible for assessing the effectiveness of the treatment, were not known to each other.
E.Double-blind means that the treatment (testosterone or placebo) assigned to a subject was unknown to the subject.

2.Explain the meaning of the term “randomized” experiment. True or False: “‘Randomized’ means that patients were randomly assigned to recieve either the testosterone suppliment or a placebo.”

A.True
B.False

3.Explain the meaning of the term “placebo-controlled” trial.

A.Placebo-controlled means that the study is an experiment rather than an observational study.
B.Placebo-controlled means that the study did not use a placebo group in its design.
C.Placebo-controlled means that the placebo group showed the same results as the treatment group.
D.Placebo-controlled means that some of the subjects were given placebo.

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